Endocrine Abstracts

Introduction: The occurence of simultaneous medullary and papillary thyroid cancer is very rare. There were only 17 case reports in the literature, and fewer with Graves-Basedow disease associated. A retrospective study conducted at the National Institute of Endocrinology ‘C. I. Parhon’ showed that 7,6%of the patients who underwent total thyroidectomy for Graves-Basedow disease had thyroid cancer. Recent studies show that specific cellular pathways are determined by ...

Background and Aims: The gut microbiome has been shown to differ between healthy individuals and those with diabetes and even in women with gestational diabetes mellitus (GDM). This raises the question of its role in postprandial glycemic response (PPGR). We aimed to evaluate the impact of microbiome features in PPGR in women with GDM and healthy pregnant women.Methods: We obtained stool samples for 96 pregnant women (65 GDM, 31 control), previously recr...

Diabetes is associated with a greatly increased risk of cardiovascular disease and the advanced glycation end products (AGEs) and their receptors play an important role in these complications.Objective: To study the association between AGEs and sRAGE levels with cardiovascular risk factors in obese and non-obese newly diagnosed type 2 diabetic patients.Material and methods: We conducted a cross-sectional study in subjects with type...

Introduction: Hypercortisolism in Cushing’s syndrome (CS) determines increased mortality and morbidity. Hypercortisolism is also present in chronic depressive disorders and stress, where telomere length (TL) is shorter than in controls. We hypothesized that telomere shortening may occur and contribute to premature morbidity in CS.Aim: Investigate TL in CS compared to matched controls, and longitudinally in a subset of CS patients evaluated both with...

Introduction: Pseudohypoparathyroidism (PHP) is a rare disorder characterized by parathormone (PTH) resistance, caused primarily by genetic defects involving the alpha-subunit of the stimulatory G protein. Biochemical and molecular analysis classify pseudohypoparathyroidism into types I-a, I-b, I-c and 2. We report a case of PHP I-b in an adolescent presenting with a neurological disorder.Case Report: 11 years old female patient, with no relevant persona...

Introduction: The mobile health (mHealth) technologies use mobiles and also wireless network and devices to offer services for improving health, promoting behavior changes and supporting self-management. The increasing global use of mobile application (app) is widely accepted in managing chronic diseases and especially among people with type 2 diabetes mellitus (T2DM).Aim: The purpose of this study was to identify the impact of the interventions based on...

Background and Aim: Over the past years, hybrid closed-loop (HCL) systems have emerged as the state-of-the art treatment of type 1 diabetes (T1D), and there is sufficient evidence to support their safety and value. The aim of this review was to evaluate all the available literature regarding the impact of HCL systems on diabetes management compared to sensor augmented pump (SAP) systems.Methods: An extensive literature search was conducted through electr...

Pituitary stalk interruption syndrome (PSIS) is a rare clinical entity characterised by an absent or thin pituitary stalk, hypoplasia of the anterior pituitary gland, and ectopic location of the posterior pituitary on magnetic resonance imaging (MRI). Presentation is on early childhood or puberty and the most common hormonal deficiencies are growth hormone (GH) and gonadotropines. We present the case of a 28-year-old female patient who consulted after 2 years in secondary amen...

Background: Dysmenorrhea is defined as pain during menstruation and might be caused by increased endometrial prostaglandin production. It is a highly prevalent medical condition (45–95% of women internationally) which can be part of a woman’s reproductive life. Throughout the literature, dysmenorrhea has been shown to affect daily functioning such as socialization, work and academic performance during menstruation and quality of life. However, dysmenorrhea and its im...

Introduction: The development of malignancies in patients with Primary Hyperparathyroidism (PHP) occurs in the context of Multiple Endocrine Neoplasia (MEN) Syndrome. The association of PTH levels with cancer in patients with sporadic PHP has not been clarified. The aim of this study was to investigate whether PTH levels are related to the presence of thyroid cancer (TH) or other types of cancer in patients with PHP.Methods: We included patients with bio...